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Algal Blooms as an Emerging Source for Novel Therapeutics for the Control of Cancer

Mark Hamann, MUSC

27 January 2017

Algal blooms play an important role in carbon cycling and the eventual sequestration of carbon generated from fossil fuel consumption. Both harmful (HABs) and benign algal blooms also provide unique opportunities for the discovery and development of novel therapeutics.  A significant limitation in the characterization and monitoring of dinoflagellate derived HAB toxins and drug leads has been the structural complexity associated with these molecules which are frequently polyketides.  In this presentation Dr. Hamann will show how the Goodman DP4 calculations combined with NMR spectroscopy can significantly expedite and improve upon the accuracy of NMR based structure assignments.  The karlotoxin class has been utilized as a model to study the strengths and limitations of these computational-spectroscopic methods of analysis with NMR.  Indeed, these types of computational tools utilized with MS and NMR are certain to revolutionize how we dereplicate, assign and monitor these highly complex marine secondary metabolites.  Due to fact that these blooms are becoming more frequent with climate change, significant opportunities exist to utilize this resource in the production of drugs.